SARS-CoV-2: do corticosteroids for fetal lung maturation worsen maternal or fetal outcomes?

Immune system changes during pregnancy could make pregnant women more susceptible to SARS-Cov-2 infection. The use of corticosteroids within obstetrics has been shown reduce the risks respiratory distress syndrome, intraventricular haemorrhage, necrotizing enterocolitis and neonatal death in baby associated with premature delivery. During COVID-19 pandemic, have trialled as a treatment dampen ‘cytokine storm’ inflammatory processes. Corticosteroids long known immunosuppressive effects that hinder body's ability mount defence against thereby delaying viral clearance. In this clinical case studies, antenatal steroids for fetal lung maturation appear be benefit did not result deterioration maternal disease. Our studies support current recommendations from Royal College Obstetricians Gynaecologists ie is appropriate patients who are suspected or confirmed SARS-CoV-2